THE POTENTIAL OF NOCALLISA (NANOCAPSULES BASED ONALLIUM ASCALONICUM SKIN) AS AN ALTERNATIVE FOR SYSTEMIC LUPUS ERYTHEMATOSUS THERAPY

Abstract

Lupus is an autoimmune inflammatory disease, one of lupus’s types is systemic lupus erythematosus (SLE). SLE is often relatedto multisystemic inflammation due to abnormal immune function.Besides that, Allium ascalonicum is the main agricultural commodity of the Indonesian people which is only used for its tubers, while the skin only become organic waste for the environment. Compounds that dominate the skin of Allium ascalonicum are quercetin (flavonoids).Quercetin has anti-inflammatory activities that have potential in the treatment of SLE. So, the researchers made an innovation by utilizing quercetin in Allium ascalonicum skinforSLE’s therapy in the form of nanocapsules so it can be consumed orally. This research used an experimental method with in-silico approach. This research proven that quercetin has potential as an anti-inflammatory agentthrough the results of PASS analysis with a Pa of 0.689. Quercetin with a single dose of the drug 1190 mg/kg known to be feasible as a drug substance with proven feasibility in various pharmaceutical aspects and 4^th toxicity shows a low level of toxic impat to the body if this nanocapsules are consumed orally.