DIABUCURE (EFFECTIVENESS TEST OF CAESALPINNIASAPPAN L WOOD AND ACALYPHA INDICA L LEAF AS ALTERNATIVE SPRAY FOR ULCUS DIABETIC TYPE 2 IN MUSMUCULUS)

Abstract

Caesalpinia sappan L wood and Acalypha indica L leaves contain flavonoids as the main compounds that significantly contribute to accelerating the healing of diabetic ulcers in Mus muculus and can impact the quality of life of the affected individuals. The aim of this research is to test the potential of Caesalpinia sappan L wood and Acalypha indica L leaves in the healing of diabetic wounds in mice and to determine the most effective formulation for Diabucure. The method used involves extracting the compounds from Caesalpinia sappan L wood and Acalypha indica L leaves to create Diabucure, inducing diabetic compounds (Alloxan monohydrate), creating wounds with a length of 1 cm and infecting them, and applying sprays with different compositions such as 100% pure extract, pure extract to alcohol ratios of 1:2 and 2:1 for 7 days. The research findings show that the wound lengths in groups T1, T2, and T3 are 0.7, 0.2, and 0.6 respectively, following the application ofDiabucure sprays containing flavonoids, terpenoids, tannins, and saponins. The spray formulation of 1:2 (T2) has a more significant effect compared to other treatments, showing a drastic reduction in wound length within 7 days. Thus, sprays containing Caesalpinia sappan L wood and Acalypha indica L leaves have the potential to be an alternative therapy for diabetic ulcers.